Obligations have been introduced in companies producing cosmetics to improve and improve the operating conditions, as a result, the GMP (Good manufacturing practices) system is designed to be used in cosmetic production areas. Contaminations should be prevented during the production phase, according to the statement, "Due to the risk of microbiological contamination varies according to the product, different production stages should be used in accordance with the industrial hygiene conditions in order to prevent any contamination risk." The hygienic sanitation supervision that we have made covers the whole production process from the acceptance of the products (raw materials, packaging materials, etc.) based on good manufacturing practices, from the storage of raw materials, packaging and final products to production, laboratory conditions and shipment.
Facilities: It should be constructed in a way to meet the conditions required by the activities to be carried out, maintained and maintained. The facility should be designed to prevent the mixing of materials and products, it should be in a way that allows cleaning, sanitization and maintenance processes to be carried out effectively and ensures the quality of the product to be maintained. Measures should be taken to prevent unauthorized persons from entering the facilities. Production, storage and quality control areas should not be used as a passage by personnel who do not work in these areas.
Goods Acceptance and Shipment Areas; Unloading and loading platforms should be designed to protect materials and products from climatic conditions. It should be designed so as not to affect storage conditions during unloading and loading.
Storage Areas; Storage areas should have sufficient capacity to allow storing materials and products from different categories on a regular basis with a shelf and pallet system.
- Placement of products and materials in storage areas will prevent dust and dirt accumulation,
It should be cleaned easily, in a way that avoids the risk of contamination and cross-contamination, and in contact with the floor and the wall.
Storage areas should be designed to include quarantine, acceptance and rejection areas for raw materials, packaging materials and finished products.
- Temperature and humidity control should be provided in accordance with the characteristics of the starting materials and products stored in the storage areas. Storage and humidity measuring devices should be kept in storage areas, and the temperature and humidity conditions of the environment should be defined and followed, and records should be kept.
- Preventive measures should be taken in a way to prevent the materials stored in the storage areas from being damaged by sunlight, there should not be any openable windows.
- Adequate and appropriate measures should be taken in production and warehouse areas where flammable, explosive, combustible raw materials and auxiliary materials to be used in production are used. The storage conditions of these substances should be arranged so as not to pose a risk.
- Rejection areas in the storage area should be created as locked areas where entrance and exit are blocked.
- Printed packaging materials should be treated carefully, and these materials should be stored in places that cannot be entered by unauthorized people and under appropriate safety conditions.
- The goods acceptance and shipment areas should be created in areas separated so as not to affect the storage conditions.
Production Areas; In order to prevent cross-contamination, there should be independent and closed areas suitable for the production of cosmetic products.
At least in accordance with the characteristics of the products produced in the cosmetic production area.
a vent with one or two-stage prefilter for suction and discharge
system must be installed. Within the scope of the maintenance of the ventilation system, the efficiency and robustness of the filters should be checked and recorded regularly.
- The chemical and microbiological quality of the water used in production is regularly written.
should be monitored and recorded within the framework of procedures. Any deviations detected should be reported and corrected with corrective actions.
- Since water is an important raw material, special care should be taken. Water production equipment
and water systems should provide quality water to guarantee the suitability of the finished product.
Deionization, filtration, distillation etc. Processes to be applied to water should be determined according to product requirements. The water system should be designed to eliminate the risk of stagnation and contamination. Regular maintenance and checks of the equipment used for the storage and transportation of water should be carried out. The water system should be sanitized according to written procedures.
- Equipment used in water system and water distribution will not affect water quality
be of material (preferably stainless steel).
- The floors, ceilings, walls and windows in the production facility are cleaned, maintained and repaired.
It should be designed to be convenient. These areas should be free of cracks and open joints, smooth, free of particulate matter and disinfectable if necessary.
- Adequate lighting should be provided for work on all areas of the facility.
The lamps to be used in lighting are protected against possible breaking situations.
It should be designed and installed in an easy-to-clean way without indentations and protrusions.
- Easy to clean pipes, drains and ducts design throughout the facility
in order not to include indentations, protrusions and hollows.
- Layout and design of the equipment include cross contamination, dust and dirt accumulation and in general
It should be done in a way to prevent any factors that negatively affect the product quality, and it should allow cleaning and maintenance operations to be carried out effectively.
- Distinctive marking and / or labeling indicating the status of any equipment used in the facility should be used. (Example: clean, dirty, in maintenance, defective, etc.)
Defective and / or defective equipment should be removed from the production or quality control area if possible.
- Measurement, weighing, recording and control equipment used in production and control processes should be periodically calibrated and checked by authorized institutions according to appropriate methods and their records should be kept.
- At least the calibration date and the next calibration date should be appropriately labeled on the calibrated equipment.
- Proper cleaning and sanitization methods should be determined in the procedures and instructions of the cleaning process, cleaning agents to be used in accordance with the areas and equipment should be defined, and records of the cleaning activities should be kept.
- Facilities will prevent pests, rodents, birds and other animals from entering.
It should be designed and built. Necessary measures to combat insects
It should be taken.
- Wastes that may occur in all areas of the facility are properly identified and assigned to them.
It should be kept tightly closed in reserved areas.
- Quality control; sampling, specifications, testing, documentation, free releases procedures and procedures. Quality control; not limited to laboratory procedures, it should be involved in making all decisions regarding product quality. The quality control unit must demonstrate that product and material quality meet the required acceptance criteria.
Quality Control Areas; Quality control laboratories should be separate from the production area and
It should be designed in accordance with the procedures to be carried out. Crosstalk and cross-contamination have sufficient space to prevent it.
- Starting materials, packaging materials, intermediate by the quality control laboratory
in order to verify compliance of the product and the finished product with the acceptance criteria
detailed records are analyzed with appropriate methods according to specified procedures.
It should be maintained.
- Laboratory reagents, solutions, reference standards should be prepared according to written procedures, and stored in areas where temperature and humidity are monitored. The solution in question and
The reagents should contain labels with the content, preparation date, name / signature of the preparer.
- A fully packed sample (including inner and outer packaging) from each batch / batch / lot of the finished product
At least 1 (one) year after the expiry date on the packaging, the finished product should be stored in storage conditions suitable for storage conditions.
Auxiliary Areas; Toilets, changing clothes and shower areas for staff are easily accessible and should be suitable for the number of users. Shower and toilet areas should be separate from production and storage areas. Maintenance workshops should be separated from production areas as much as possible. If spare parts and tools are stored in production areas, these parts and tools should be stored in rooms or cabinets reserved for this purpose.
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